I create each comic in three formats: a full-size version for print, a square version suitable for mobile devices, and a vertical scroll for reading on small screens. I work on each panel in its own file, drawing it once and then adjusting its layout to fit each format. The first two images show the original panel in its own file and how it looks in its final format. This method requires more work at the beginning of each comic, but it gives me greater flexibility and, in my opinion, a better end result.